发明授权
US4640798A Intermediates for the preparation of penicillin and cephalosporin
compounds
失效
用于制备青霉素和头孢菌素化合物的中间体
- 专利标题： Intermediates for the preparation of penicillin and cephalosporin compounds
- 专利标题（中）： 用于制备青霉素和头孢菌素化合物的中间体
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申请号： US761717申请日： 1985-08-02
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公开(公告)号： US4640798A公开(公告)日： 1987-02-03
- 发明人: John R. Corfield , Andrew S. Miller
- 申请人： John R. Corfield , Andrew S. Miller
- 申请人地址： GB2 London
- 专利权人： Lilly Industries Ltd.
- 当前专利权人： Lilly Industries Ltd.
- 当前专利权人地址： GB2 London
- 主分类号： C07D499/00
- IPC分类号： C07D499/00 ; C07D499/10 ; C07D501/04 ; C07F7/10 ; C07D501/02 ; A61K31/545
摘要：
There is described a process for preparing a sulphoxide of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4, taken individually, are alkyl, alkoxy or aryl groups, X is an alkylene group, R.sup.5 is a carboxylic acid protecting group and Y is a linking group through one or two carbon atoms forming a penam or cephem nucleus, which comprises reacting a compound of formula ##STR2## with an oxidizing agent. .alpha.-Sulphoxide compounds of formula (I) are also provided as novel intermediates.
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