发明授权
US4654337A Perfluoro-1-azatricyclic amine compounds useful as blood substitutes or
in infusion fluids
失效
全氟-1-氮杂环胺化合物可用作血液代用品或输注液
- 专利标题： Perfluoro-1-azatricyclic amine compounds useful as blood substitutes or in infusion fluids
- 专利标题（中）： 全氟-1-氮杂环胺化合物可用作血液代用品或输注液
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申请号： US751880申请日： 1985-07-05
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公开(公告)号： US4654337A公开(公告)日： 1987-03-31
- 发明人: Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Yoshihisa Inoue , Youichiro Naito , Tadakazu Suyama
- 申请人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Yoshihisa Inoue , Youichiro Naito , Tadakazu Suyama
- 申请人地址： JPX Osaka
- 专利权人： The Green Cross Corporation
- 当前专利权人： The Green Cross Corporation
- 当前专利权人地址： JPX Osaka
- 优先权： JPX57-137663 19820807; JPX57-137664 19820807; JPX57-137665 19820807
- 主分类号： A61K9/00
- IPC分类号： A61K9/00 ; C07D453/02 ; C07D471/08 ; C07D487/08 ; C25B3/08 ; C07D223/00 ; A61K31/435
摘要：
A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 or 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.