发明授权
- 专利标题: Furoxanthone derivatives useful as diuretics
- 专利标题(中): 呋喃西酮衍生物可用作利尿剂
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申请号: US775240申请日: 1985-09-12
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公开(公告)号: US4661607A公开(公告)日: 1987-04-28
- 发明人: Hiroshi Koga , Takashi Mori , Takashi Dan , Michitaka Akima
- 申请人: Hiroshi Koga , Takashi Mori , Takashi Dan , Michitaka Akima
- 申请人地址: JPX Tokyo
- 专利权人: Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人: Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX59-196796 19840921; JPX59-204351 19840928
- 主分类号: A61K31/35
- IPC分类号: A61K31/35 ; C07D311/86 ; C07D493/04
摘要:
Xanthone derivatives of the formula (I): ##STR1## (wherein W, X, Y and Z which may be the same or different represent a hydrogen atom, a halogen atom or a lower alkyl group having 1 to 4 carbon atoms; A is hydrogen atom or together with Z forms a --CH.sub.2 -- group which binds to a phenyl carbon adjacent the phenyl carbon to which the oxygen of the group ##STR2## is attached to form a cyclic methylene chain; B is a hydroxymethyl group, a lower alkoxycarbonyl group having 1 to 4 carbon atoms, or a carboxyl group, provided that W is neither a hydrogen atom nor a 7-position methyl group when X, Y and Z are each a hydrogen atom, and A is a hydrogen atom and B is a carboxyl group or a lower alkoxycarbonyl group), as well as non-toxic salts thereof when B is a carboxyl group, and a process for preparing the same are disclosed.The compounds of formula (I) in accordance with the present invention are useful as diuretics having uricosuric activity and can be used in the treatment of edema or hypertension.
公开/授权文献
- US5851123A Multiple socket compatible plug 公开/授权日:1998-12-22
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