发明授权
US4663486A Conversion of prostaglandin analogs into a bicarbonate insoluble
oligomeric mixture
失效
将前列腺素类似物转化为碳酸氢盐不溶性低聚物混合物
- 专利标题： Conversion of prostaglandin analogs into a bicarbonate insoluble oligomeric mixture
- 专利标题（中）： 将前列腺素类似物转化为碳酸氢盐不溶性低聚物混合物
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申请号： US492088申请日： 1983-05-06
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公开(公告)号： US4663486A公开(公告)日： 1987-05-05
- 发明人: George L. Nelson
- 申请人： George L. Nelson
- 申请人地址： DC Washington
- 专利权人： The United States of America as represented by the Secretary of the Navy
- 当前专利权人： The United States of America as represented by the Secretary of the Navy
- 当前专利权人地址： DC Washington
- 主分类号： C07C405/00
- IPC分类号： C07C405/00 ; C07C45/70
摘要：
A method for oligomerization of a group of prostaglandin analogs such as Ethyl Analog 3-(trans-3-keto-1-pentenyl)-2-ethyl-2-cyclopentenone into a biologically active exhibiting protection of oxidative phosphorylation of degenerated mitochondria and sodium bicarbonate insoluble oligomeric mixtures is described. The Ethyl Analog is treated with ethanolic potassium hydroxide solution in an oxygen-free atomsphere at moderate conditions of temperature, time and concentration.
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