发明授权
- 专利标题: Avermectin bioconversion products
- 专利标题(中): 阿维菌素生物转化产物
-
申请号: US830333申请日: 1986-02-20
-
公开(公告)号: US4666937A公开(公告)日: 1987-05-19
- 发明人: Robert T. Goegelman , Edward S. Inamine , Raymond F. White
- 申请人: Robert T. Goegelman , Edward S. Inamine , Raymond F. White
- 申请人地址: NJ Rahway
- 专利权人: Merck & Co., Inc.
- 当前专利权人: Merck & Co., Inc.
- 当前专利权人地址: NJ Rahway
- 主分类号: C07D493/22
- IPC分类号: C07D493/22 ; A01N43/90 ; A23K1/16 ; A61K31/365 ; A61P33/10 ; C07H19/01 ; C12P17/08 ; C12P17/18 ; C12P19/44 ; C12R1/645
摘要:
There are disclosed novel compounds which are derived from 22,23-dihydro avermectin Bla aglycone, 13-deoxy-22,23 dihydro overmectin Bla aglycone and 13-deoxy-22,23-dihydro overmectin Blb aglycone. The six compounds are hydroxy adducts of the substrate avermectin compound at the 12a, 24, 24a, 26, 26a and 27 positions. The hydroxy adducts are prepared by incubating the substrate with the microorganism Cunninghamella blakesleeana and isolating the hydroxy adducts from the fermentation broth. The compounds are highly potent antiparasitic, insecticidal and anthelmintic agents.
公开/授权文献
- US5283063A Punctum plug method and apparatus 公开/授权日:1994-02-01