发明授权
- 专利标题: Chlorination process
- 专利标题(中): 氯化工艺
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申请号: US848969申请日: 1986-04-07
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公开(公告)号: US4675448A公开(公告)日: 1987-06-23
- 发明人: Barbara C. Stahly
- 申请人: Barbara C. Stahly
- 申请人地址: VA Richmond
- 专利权人: Ethyl Corporation
- 当前专利权人: Ethyl Corporation
- 当前专利权人地址: VA Richmond
- 主分类号: C07C45/46
- IPC分类号: C07C45/46 ; C07C45/63 ; C07C49/84
摘要:
1-[2,5-Bis(2,2,2-trifluoroethoxy)phenyl]ethanone is chlorinated to 1-[2,5-bis(2,2,2-trifluoroethoxy)phenyl]-2,2-dichloroethanone and, if desired, to 1-[2,5-bis(2,2,2-trifluoroethoxy)phenyl]-2,2,2-trichloroethanone in a solvent mixture of about 0.5-35 parts by volume of 1,2-dichloroethane and one part by volume of acetic acid. The products can then be converted to flecainide. In a preferred embodiment of the invention, the starting material is a crude, wet material that is prepared with a minimum of solids handling.
公开/授权文献
- US4176118A Aromatic uretdione-diisocyanate-disulphonic acids 公开/授权日:1979-11-27
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