发明授权
- 专利标题： Temperature sensitive reassortant viruses and a vaccine against equine influenza
- 专利标题（中）： 温度敏感性重配病毒和针对马流感的疫苗
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申请号： US634510申请日： 1984-07-26
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公开(公告)号： US4683137A公开(公告)日： 1987-07-28
- 发明人: Leroy Coggins , Brian R. Murphy , Dorothy F. Holmes , Lynne J. Anguish , James H. Gillespie
- 申请人： Leroy Coggins , Brian R. Murphy , Dorothy F. Holmes , Lynne J. Anguish , James H. Gillespie
- 申请人地址： NY Ithaca
- 专利权人： Cornell Research Foundation, Inc.
- 当前专利权人： Cornell Research Foundation, Inc.
- 当前专利权人地址： NY Ithaca
- 主分类号： A61K39/145
- IPC分类号： A61K39/145 ; C12N7/00 ; A61K39/12
摘要：
This invention relates to a method and resulting temperature-sensitive (ts) reassortant virus produced by modifying wild-type equine influenza viruses by utilizing mutagenized human influenza viruses possessing ts lesions and shut off temperatures in the area of 37.degree.-39.degree. C., preferably 37.degree.-38.degree. C. When utilized as a vaccine for equines, these temperature-sensitive recombinant viruses have the facility to develop only mild symptoms while producing protection against infectious equine influenzal disease.
公开/授权文献
- US5686783A Cementless electrical lamp-base combination 公开/授权日：1997-11-11
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