A dentifrice dispensing toothbrush is described which stores dentifrice material in its handle and deposits a controlled portion of the stored material directly onto the top of the brush surface. The toothbrush comprises (1) a housing which includes a handle, (2) a reservoir situated within the housing for storing dentifrice material, (3) a brush having bristles which are attached to and supported by a head member, (4) an applicator which is attached to the housing and which is used to deposit portions of the material directly onto the top of the brush surface, (5) a valve which controls the flow of dentifrice material from the reservoir to the applicator and (6) a pumping means for applying pressure to the stored dentifrice material so as to cause it to flow from the reservoir to the applicator. The dentrifrice material is stored either directly in the reservoir or in a removable cartridge which is inserted in the reservoir. The cartridge comprises a hollow cylinder and a backstop which is a circular shaped disc positioned within the cylinder.The toothbrush is operated by depressing the brush member which causes dentifrice material to be pumped from the reservoir. This is coupled with a simultaneous action of extending the applicator to dispense a controlled portion of dentifrice material directly onto the top surface of the brush. The toothbrush can be conveniently and efficiently operated with one hand. Its features make it particularly suitable for use by the physically handicapped.