发明授权
- 专利标题: Hydrazinopyridazine compounds
- 专利标题(中): 肼基哒嗪化合物
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申请号: US479913申请日: 1983-03-28
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公开(公告)号: US4711887A公开(公告)日: 1987-12-08
- 发明人: Malcolm T. Briggs , Robert I. Dowell , Craig W. Thornber
- 申请人: Malcolm T. Briggs , Robert I. Dowell , Craig W. Thornber
- 申请人地址: GB2 London
- 专利权人: Imperial Chemical Industries PLC
- 当前专利权人: Imperial Chemical Industries PLC
- 当前专利权人地址: GB2 London
- 优先权: GBX8211760 19820423
- 主分类号: A61K31/50
- IPC分类号: A61K31/50 ; A61K31/502 ; A61P9/12 ; C07D237/14 ; C07D237/18 ; C07D237/20 ; C07D237/22 ; C07D237/24 ; C07D237/32 ; C07D237/34
摘要:
Hydrazinopyridiazine derivatives of the formula: ##STR1## wherein A is alkylene, wherein either R.sup.1 is hydrogen and R.sup.2 is hydrogen, alkoxycarbonyl or aralkoxycarbonyl, or R.sup.1 and R.sup.2 together form alkylidene, aralkylidene, alkoxycarbonylalkylidene or aralkoxycarbonylalkylidene, wherein either R.sup.3 and R.sup.4, which may be the same or different, each is hydrogen, halogen, hydroxy, amino, nitro, trifluoromethyl, carbamoyl, cyano, alkyl, hydroxyalkyl, cycloalkyl, alkenyl, alkynyl, alkoxy, alkylthio, cycloalkoxy, alkenyloxy, alkynyloxy, alkanoyl, aryl, aryloxy or dialkylamino, or R.sup.3 and R.sup.4 together with the adjacent benzene ring form indanyl, 5,6,7,8-tetrahydronaphthyl, 5-oxo-5,6,7,8-tetrahydronaphthyl, indenyl, 5,8-dihydronaphthyl or naphthyl, wherein either R.sup.5 and R.sup.6, which may be the same or different, each is hydrogen or alkyl, or R.sup.5 and R.sup.6 together with the adjacent pyridazine ring form phthalazinyl, and wherein X is oxygen or --NHCO--, --NHCO--A.sup.1 -- or --NHCO--A.sup.1 --O-- wherein A.sup.1 is alkylene, acid-addition salts thereof, processes for their manufacture and pharmaceutical composition containing them. The compounds possess antihypertensive activity.