发明授权
- 专利标题： Lysosometropic detergent therapeutic agents
- 专利标题（中）： 溶血性视神经洗涤剂治疗剂
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申请号： US902136申请日： 1986-09-02
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公开(公告)号： US4719312A公开(公告)日： 1988-01-12
- 发明人: Raymond A. Firestone
- 申请人： Raymond A. Firestone
- 申请人地址： NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： NJ Rahway
- 主分类号： A61K31/13
- IPC分类号： A61K31/13 ; A61K31/15 ; A61K31/155 ; A61K31/27 ; A61K31/275 ; A61K31/415 ; A61K31/425 ; A61K31/44 ; A61K31/495 ; A61K31/535 ; A61K31/575 ; A61K31/675 ; A61K38/00 ; A61K47/48 ; C07D521/00 ; C07J43/00 ; C07K5/06 ; C07K5/072 ; C07C87/22
摘要：
The present invention is concerned with the preparation of lysosomotropic detergent agents and pharmaceutical composition useful in the treatment of cancer. These compounds are amine derivatives having a pK of 3.5 of the general structure ##STR1## in which R.sub.1 is C.sub.8-30 alkyl, C.sub.8-30 -alkenyl, substituted C.sub.4-30 alkyl or substituted C.sub.4-30 -alkenyl; R.sub.2 is hydrogen or C.sub.1-4 alkyl and Y is an electron withdrawing group, to control the pK, selected from trifluoroethyl, and difluoroethyl.
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