发明授权
US4722926A Substituted phenylalkyl-(piperazinyl or homopiperazinyl)alkyl thiols and
thiocarbamates useful for the treatment of immunological, inflammatory,
and allergic disorders
失效
可用于治疗免疫学,炎症和过敏性疾病的取代的苯基烷基 - (哌嗪基或高哌嗪基)烷基硫醇和硫代氨基甲酸酯
- 专利标题: Substituted phenylalkyl-(piperazinyl or homopiperazinyl)alkyl thiols and thiocarbamates useful for the treatment of immunological, inflammatory, and allergic disorders
- 专利标题(中): 可用于治疗免疫学,炎症和过敏性疾病的取代的苯基烷基 - (哌嗪基或高哌嗪基)烷基硫醇和硫代氨基甲酸酯
-
申请号: US889106申请日: 1986-07-23
-
公开(公告)号: US4722926A公开(公告)日: 1988-02-02
- 发明人: Karl D. Hargrave , John P. Devlin , Edward A. Barsumian
- 申请人: Karl D. Hargrave , John P. Devlin , Edward A. Barsumian
- 申请人地址: CT Ridgefield
- 专利权人: Boehringer Ingelheim Limited
- 当前专利权人: Boehringer Ingelheim Limited
- 当前专利权人地址: CT Ridgefield
- 主分类号: C07D241/04
- IPC分类号: C07D241/04 ; C07D243/08 ; C07D295/088 ; A61K31/33
摘要:
Compounds of the formula ##STR1## wherein R is hydrogen or ##STR2## A is alkyl of 1 to 8 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; phenyl; or phenyl mono-, di- or tri-substituted independently with alkyl of 1 to 4 carbon atoms, halogen, trihalomethyl, alkoxy of 1 to 3 carbon atoms, carboxylic acyl of 1 to 3 carbon atoms, carboxyl, (alkoxy of 1 to 3 carbon atoms)carbonyl, nitro, cyano or di(alkyl of 1 to 3 carbon atoms)amino;R.sub.1, R.sub.2 and R.sub.3, are independently hydrogen, halogen, alkyl of 1 to 4 carbon atoms, trihalomethyl, nitro, cyano, di(alkyl of 1 to 4 carbon atoms)amino, (alkoxy of 1 to 4 carbon atoms)carbonyl, alkoxy of 1 to 4 carbon atoms or hydroxyl;R.sub.4 and R.sub.5 are independently hydrogen, alkyl of 1 to 4 carbon atoms, or phenyl;R.sub.6, R.sub.7, R.sub.8 and R.sub.9 are independently hydrogen or methyl;Y is --CH.sub.2 -- or --CH.sub.2 --CH.sub.2 --;j is 0 to 1;k and m are independently 0, 1, 2, or 3, their sum being no more than 6 and must be 0 when j is 1;n is 2, 3, or 4, with the proviso that n must be 3 or 4 when R.sub.1 is hydrogen or 2-methyl, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and R are each and j, k, and m are each 0, and Y is --CH.sub.2 --;and non-toxic, pharmaceutically acceptable acid addition salts thereof are useful for the treatment of immunological, inflammatory and allergic disorders.