发明授权
- 专利标题： GnRH antagonists VIII
- 专利标题（中）： GnRH拮抗剂VIII
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申请号： US946454申请日： 1986-12-23
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公开(公告)号： US4740500A公开(公告)日： 1988-04-26
- 发明人: Wylie W. Vale, Jr. , Jean E. F. Rivier
- 申请人： Wylie W. Vale, Jr. , Jean E. F. Rivier
- 申请人地址： CA San Diego
- 专利权人： The Salk Institute for Biological Studies
- 当前专利权人： The Salk Institute for Biological Studies
- 当前专利权人地址： CA San Diego
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K7/23 ; A61K37/43 ; C07K7/20
摘要：
Peptides which inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads. Administration of an effective amount prevents ovulation of female mammalian eggs and/or the release of steroids by the gonads. The peptides have the structure: Ac-.beta.-D-NAL-R.sub.2 -D-3PAL-Ser-Arg-R.sub.6 -Leu-Arg-Pro-R.sub.10 wherein R.sub.2 is Cl-D-Phe, F-D-Phe, NO.sub.2 -D-Phe, Br-D-Phe, 3,4Cl.sub.2 -D-Phe or C.alpha.Me-Cl-D-Phe; R.sub.6 is D-3PAL, D-Trp, For-D-Trp, NO.sub.2 -D-Trp, (imBzl)D-His, D-Tyr or .beta.-D-NAL; and R.sub.10 is Gly-NH.sub.2, NHCH.sub.2 CH.sub.3, NHNHCONH.sub.2 or D-Ala-NH.sub.2.
公开/授权文献
- US5933281A Zoom lens system 公开/授权日：1999-08-03
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