In an electronic fuel injection control device for an internal combustion engine, an A-D converter is provided to convert an analogue signal indicative of a physical value such as an intake manifold negative pressure or an amount of suction air to a digital value, and a computer is programmed to calculate an average of a plurality of the digital values successively converted during one rotation of the engine, to determine whether or not a difference between the preceding average of the digital signals and the following average of the digital signals is larger than a predetermined value indicative of a transient operation of the engine, if so determine a first optimum physical value based on an average of at least two digital values most newly converted during one rotation of the engine, and if not determine a second optimum physical value based on the average of the digital values, and to determine an optimum fuel injection time based on one of the first and second optimum physical values and in relation to rotational speed of the engine.