发明授权
- 专利标题: Process for the preparation of an apovincaminol derivative
- 专利标题(中): 阿朴菌素衍生物的制备方法
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申请号: US861550申请日: 1986-05-09
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公开(公告)号: US4758666A公开(公告)日: 1988-07-19
- 发明人: Janos Galambos , Tibor Keve , Bela Stefko , Gyorgy Fekete , Bela Zsadon , Anna Kassai nee Zieger , Klara Horvath nee Otta
- 申请人: Janos Galambos , Tibor Keve , Bela Stefko , Gyorgy Fekete , Bela Zsadon , Anna Kassai nee Zieger , Klara Horvath nee Otta
- 申请人地址: HUX Budapest
- 专利权人: Richter Gedeon Vegyeszeti Gyar R.T.
- 当前专利权人: Richter Gedeon Vegyeszeti Gyar R.T.
- 当前专利权人地址: HUX Budapest
- 优先权: HUX1758/85 19850510
- 主分类号: C07D461/00
- IPC分类号: C07D461/00
摘要:
The invention relates to a new process for the preparation of 17,18-dehydro-apovincaminol-trimethoxy-benzoate of the formula (I) ##STR1## and acid addition salts thereof. According to the invention compound of the formula (I) is prepared starting from 17,18-dehydrovincamine of the formula (IIa) ##STR2## and/or 17,18-dehydro-epivincamine of formula (IIb) ##STR3## by reducing with a complex metal hydride, acylating the new hydroxy-vincaminol derivative obtained selectively with 3,4,5-trimethoxy-benzoic acid or a derivative thereof capable of acylation, optionally in the presence of a catalyst and/or an acid binding agent, and treating the corresponding acylated hydroxylderivative obtained with formic acid, in the presence of an acid chloride, and, if desired, converting the compound of formula (I) obtained into an acid addition salt thereof.
公开/授权文献
- US5833198A Mechanically operated lift table 公开/授权日:1998-11-10