发明授权
US4762823A Nucleosides of 5-monofluoromethyluracil and 5-difluoromethyluracil
失效
5-单氟甲基尿嘧啶和5-二氟甲基尿嘧啶的核苷
- 专利标题： Nucleosides of 5-monofluoromethyluracil and 5-difluoromethyluracil
- 专利标题（中）： 5-单氟甲基尿嘧啶和5-二氟甲基尿嘧啶的核苷
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申请号： US787973申请日： 1985-10-16
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公开(公告)号： US4762823A公开(公告)日： 1988-08-09
- 发明人: Kyoichi A. Watanabe , Jasenka Matulic-Adamic , Richard W. Price , Jack J. Fox
- 申请人： Kyoichi A. Watanabe , Jasenka Matulic-Adamic , Richard W. Price , Jack J. Fox
- 申请人地址： NY New York
- 专利权人： Sloan-Kettering Institute for Cancer Research
- 当前专利权人： Sloan-Kettering Institute for Cancer Research
- 当前专利权人地址： NY New York
- 主分类号： A61K51/00
- IPC分类号： A61K51/00 ; A61K31/70 ; A61K31/7042 ; A61K31/7052 ; A61K31/7064 ; A61K31/7072 ; A61P31/12 ; A61P35/00 ; C07H19/06
摘要：
A method for synthesizing monofluoromethyl- and difluoromethyluracil nucleosides from the corresponding thymine nucleosides is developed. These compounds which contain a partially fluorinated methyl group at the C-5 position (a new class of nucleosides) are potential antiviral and/or anticancer agents. The major features of the preparative route involve bromination of suitably protected thymine nucleosides followed by fluoride treatment.
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