发明授权
US4766128A Optionally 11- to 13-substituted ergoline compounds useful as medicinal
agents
失效
任选地，可用作药物的11至13个取代的麦角灵化合物
- 专利标题： Optionally 11- to 13-substituted ergoline compounds useful as medicinal agents
- 专利标题（中）： 任选地，可用作药物的11至13个取代的麦角灵化合物
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申请号： US589376申请日： 1984-03-14
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公开(公告)号： US4766128A公开(公告)日： 1988-08-23
- 发明人: Gerhard Sauer , Gregor Haffer , Helmut Wachtel , Herbert H. Schneider , Wolfgang Kehr
- 申请人： Gerhard Sauer , Gregor Haffer , Helmut Wachtel , Herbert H. Schneider , Wolfgang Kehr
- 申请人地址： DEX Berlin and Bergkamen
- 专利权人： Schering Aktiengesellschaft
- 当前专利权人： Schering Aktiengesellschaft
- 当前专利权人地址： DEX Berlin and Bergkamen
- 优先权： DEX3309493 19830314
- 主分类号： A61K31/48
- IPC分类号： A61K31/48 ; A61P9/12 ; A61P25/00 ; A61P25/20 ; A61P25/24 ; A61P25/26 ; C07D457/12
摘要：
Substituted ergolines of the formula ##STR1## and their acid addition salts, wherein the urea side chain in the 8-position can be in the d.alpha.- or .beta.-configuration, C.sub.2 C.sub.3 and C.sub.9 C.sub.10 are a CC single or C.dbd.C double bond, andR is hydrogen or NR'R" wherein R'R" is O.sub.2, H.sub.2, C.sub.1-4 -dialkyl, or, together, they form a 3- to 9-membered ring, or R' and R" individually are hydrogen, C.sub.1-4 -alkyl, or C.sub.1-10- -acyl,R.sup.1 is hydrogen, C.sub.1-4 -alkyl, C.sub.1-10 -acyl, C.sub.6-8 -aryl, or C.sub.1-4 -alkylsulfonyl,R.sup.2 is hydrogen or halogen if C.sub.2 C.sub.3 is a C.dbd.C double bond, or hydrogen if C.sub.2 C.sub.3 is a CC single bond,R.sup.6 is C.sub.1-4 -alkyl,show a pronounced effect on the central nervous system and are suitable, for example, as antidepressants, neuroleptics, or antihypertensives.
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