Boron compounds are separated and recovered from a geothermal brine, which additionally contains inorganic salts, such as sodium and potassium chlorides and sulphates, by means of a process comprising the following process steps:(a) pre-concentration of the geothermal brine by expansion up to room pressure, to a pressure lower than room pressure;(b) concentration of the pre-concentrated brine, coming from the (a) step, by means of an osmotic treatment against a concentrated aqueous solution of recycled inorganic salts;(c) treatment of crystallization of the concentrated brine, coming from the (b) step, with the separation of the solid inorganic salts from an aqueous solution of boron compounds;(d) recycle of the inorganic salts separated in the (c) step, to the (b) step of osmosis, in the form of a concentrated aqueous solution; and(e) recovery of boron compounds from the relevant aqueous solution obtained in the (c) step.