发明授权
- 专利标题: Pyrazol and indazolpyridinamines
- 专利标题(中): 吡唑和吲唑吡啶胺
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申请号: US141852申请日: 1988-01-11
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公开(公告)号: US4806554A公开(公告)日: 1989-02-21
- 发明人: Richard C. Effland , Joseph T. Klein
- 申请人: Richard C. Effland , Joseph T. Klein
- 申请人地址: NJ Somerville
- 专利权人: Hoechst-Roussel Pharmaceuticals, Inc.
- 当前专利权人: Hoechst-Roussel Pharmaceuticals, Inc.
- 当前专利权人地址: NJ Somerville
- 主分类号: C07D401/12
- IPC分类号: C07D401/12 ; A61K31/44 ; A61K31/4427 ; A61P25/04 ; A61P25/24 ; A61P25/26 ; C07D401/04 ; C07D521/00 ; A61K31/415
摘要:
There are described compounds of the formula ##STR1## where n is 0 or 1; R.sub.1 is independently hydrogen, loweralkyl, loweralkenyl, loweralkynyl, loweralkoxycarbonylloweralkyl, loweralkylaminocarbonylloweralkyl, aminocarbonylloweralkyl, arylloweralkyl, phenyl, nitrophenyl, cyanophenyl, trifluoromethylphenyl, aminophenyl, loweralkanoylaminophenyl, loweralkoxycarbonyl, arylloweralkoxycarbonyl, aryloxycarbonyl, loweralkylaminocarbonyl, arylloweralkylaminocarbonyl, arylaminocarbonyl, alkanoyl, arylloweralkanoyl, aroyl, alkenoyl, alkynoyl or --R.sub.5 --NR'R" where R.sub.5 is loweralkylene, loweralkenylene or loweralkynylene and R' and R" are each independently loweralkyl or alternatively the group --NR'R" as a whole is 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 4-loweralkyl-1-piperazinyl or 4-aryl-1-piperazinyl;R.sub.2 is hydrogen or loweralkyl;R.sub.3 and R.sub.4 are each independently hydrogen or loweralkyl, or alternatively R.sub.3 and R.sub.4 taken together form --CH.dbd.CH--CH.dbd.CH-- so that the moiety ##STR2## becomes an indazole ring; and X is hydrogen, nitro, amino, halogen, loweralkanoylamino, arylloweralkanoylamino, aroylamino, alkylamino, arylloweralkylamino, loweralkyl, and cyano; which compounds are useful as analgesic and antidepressant agents.
公开/授权文献
- US6024508A Folio having flip-over pad 公开/授权日:2000-02-15
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