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发明授权
US4824834A Pyrazolotriazine compounds 失效
吡唑并三嗪化合物

Pyrazolotriazine compounds
摘要：
Pyrazolotriazine compounds of the formula: ##STR1## wherein R.sup.1 is OH or alkanoyloxy; R.sup.2 is H, OH, or SH; R.sup.3 is (1) unsaturated N- or S-containing heterocyclic group optionally having 1-2 substituents of halogen, nitro or phenylthio, (2) naphthyl, (3) phenyl optionally having 1-3 substituents of (i) alkyl, (ii) phenyl, (iii) alkoxycarbonyl, (iv) cyano, (v) nitro, (vi) alkoxy, (vii) phenylalkoxy (viii) phenylthio-alkyl, (ix) phenoxy, (x) ##STR2## R is alkyl, halo-substituted alkyl, phenyl optionally having 1-3 substituents, or pyridyl, and l is 0, 1 or 2, (xi) halogen, (xii) phenylalkyl, (xiii) carboxy, (xiv) alkanoyl, (xv) benzoyl optionally having 1-3 substituents, (xvi) amino, (xvii) OH, (xviii) alkanoyloxy, (xix) ##STR3## or (xx) ##STR4## (A is alkylene), said compounds having a xanthine oxidase inhibitory activity and are useful for the prophylaxis and treatment of gout.
摘要（中）：

下式的吡唑并三嗪化合物：其中R1是OH或烷酰氧基; R2是H，OH或SH; R3是（1）任选具有1-2个卤素取代基的不饱和N-或S-杂环基，硝基或苯硫基，（2）萘基，（3）任选具有1-3个（i）烷基取代基的苯基，（ii） ）苯基，（iii）烷氧基羰基，（iv）氰基，（ⅴ）硝基，（vi）烷氧基，（i）苯基烷氧基（ii）苯硫基烷基，（ix）苯氧基，（Ⅹ） 取代的烷基，任选具有1-3个取代基的苯基或吡啶基，l是0,1或2，（xi）卤素，（xii）苯基烷基，（xiii）羧基，（xiv）烷酰基，（xv） 1-3取代基，（xvi）氨基，（xvii）OH，（xviii）烷酰氧基，（xix）或（xx）（A是亚烷基），所述化合物具有黄嘌呤氧化酶抑制活性， 用于预防和治疗痛风。

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