发明授权
- 专利标题: Tricyclic benzotriazoles, processes for the preparation thereof and pharmaceutical compositions containing them
- 专利标题(中): 三环苯并三唑,其制备方法和含有它们的药物组合物
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申请号: US80658申请日: 1987-08-03
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公开(公告)号: US4835167A公开(公告)日: 1989-05-30
- 发明人: Wolfgang Von Der Saal , Walter-Gunar Friebe , Alfred Mertens , Bernd Muller-Beckmann , Gisbert Sponer
- 申请人: Wolfgang Von Der Saal , Walter-Gunar Friebe , Alfred Mertens , Bernd Muller-Beckmann , Gisbert Sponer
- 申请人地址: DEX Mannheim
- 专利权人: Boehringer Mannheim GmbH
- 当前专利权人: Boehringer Mannheim GmbH
- 当前专利权人地址: DEX Mannheim
- 优先权: DEX3626664 19860807
- 主分类号: C07D487/04
- IPC分类号: C07D487/04 ; C07D487/10 ; C07D498/04 ; C07D513/04
摘要:
The present invention provides new tricyclic benzotriazoles of the general formula: ##STR1## wherein Z is a hydrogen atom or an acyl radical, Y is an oxygen or sulphur atom or two hydrogen atoms and X is an oxygen or sulphur atom or a >CR.sub.1 R.sub.2 or >NR.sub.3 group, R.sub.1 is a hydrogen atom or an alkyl, alkenyl or cycloalkyl radical, R.sub.2 is a hydrogen atom or an alkyl, alkenyl or cyano group or a carbonyl group substituted by a hydroxyl, alkyl, alkoxy, amino, alkylamino, dialkylamino or hydrazino group or R.sub.2, together with R.sub.1, represents a cycloalkylene radical or R.sub.1 and R.sub.2 together form an alkylidene or cycloalkylidene radical and R.sub.3 is a hydrogen atom or an alkyl radical; the tautomers thereof and the physiologically acceptable acid-addition salts thereof with inorganic and organic acids.The present invention also provides processes for the preparation of these tricyclic benzotriazoles and pharmaceutical compositions containing them for the treatment of heart and circulatory diseases.
公开/授权文献
- US6096616A Fabrication of a non-ldd graded p-channel mosfet 公开/授权日:2000-08-01
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