发明授权
- 专利标题： Polypeptide cartilage-inducing factors found in bone
- 专利标题（中）： 在骨中发现的多肽软骨诱导因子
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申请号： US204173申请日： 1988-06-08
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公开(公告)号： US4843063A公开(公告)日： 1989-06-27
- 发明人: Saeid Seyedin , Thomas Thomas , Hanne Bentz , Larry Ellingsworth , Rosa Armstrong
- 申请人： Saeid Seyedin , Thomas Thomas , Hanne Bentz , Larry Ellingsworth , Rosa Armstrong
- 申请人地址： CA Palo Alto
- 专利权人： Collagen Corporation
- 当前专利权人： Collagen Corporation
- 当前专利权人地址： CA Palo Alto
- 主分类号： A61K35/32
- IPC分类号： A61K35/32 ; A61K38/00 ; A61L27/22 ; C07K14/495
摘要：
Two proteins that are found in bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. Each is reduced to a single polypeptide indicating that the proteins are probably homodimers. One has an N-terminal sequence identical to that of human placenta-derived TGF-.beta. whereas the other has an N-terminal sequence that is different from that of TGF-.beta. derived from human placenta. The two proteins may be purified to hmogeneity using RP-HPLC or acetic acid-urea gel electrophoresis.
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