发明授权
- 专利标题: Morpholine containing pyridine compounds, compositions and use
- 专利标题(中): 含有吡啶化合物的吗啉,组成和用途
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申请号: US184195申请日: 1988-04-21
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公开(公告)号: US4857527A公开(公告)日: 1989-08-15
- 发明人: Takao Takaya , Hisashi Takasugi , Kimio Esumi , Atsushi Kuno , Hiroyoshi Sakai , Kazuhiro Maeda , Yoshie Sakamoto
- 申请人: Takao Takaya , Hisashi Takasugi , Kimio Esumi , Atsushi Kuno , Hiroyoshi Sakai , Kazuhiro Maeda , Yoshie Sakamoto
- 申请人地址: JPX Osaka
- 专利权人: Fujisawa Pharmaceutical Co., Ltd.
- 当前专利权人: Fujisawa Pharmaceutical Co., Ltd.
- 当前专利权人地址: JPX Osaka
- 优先权: GBX8530602 19851212; JPX62-145996 19870611; JPX62-251771 19871005
- 主分类号: C07D213/82
- IPC分类号: C07D213/82
摘要:
An N-containing heterocyclic compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl optionally substituted with hydroxy, halogen or a heterocyclic group, carboxy, esterified carboxy, carbamoyl optionally substituted with heterocyclic(lower)alkyl or lower alkylamino(lower)alkyl, N-containing heterocycliccarbonyl optionally substituted with lower alkyl, or ureido optionally substituted with lower alkylamino(lower)alkyl, andR.sup.3 is hydrogen or halogen;R.sup.2 is phenyl substituted with nitro, andX is .dbd.N--or ##STR2## in which R.sup.4 is lower alkyl or halo(lower)alkyl, or is taken together with R.sup.1 to form an N-containing heterocyclic group optionally substituted with oxo and lower alkylamino(lower)alkyl; orR.sup.2 is lower alkyl, andX is ##STR3## in which R.sup.4 is phenyl substituted with nitro; and a pharmaceutically acceptable salt thereof, processes for the preparation thereof and pharmaceutical (e.g. antihypertension) compositions comprising the same.
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