发明授权
- 专利标题： Method of treating tumors using tetracyclo compounds
- 专利标题（中）： 使用四环化合物治疗肿瘤的方法
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申请号： US947759申请日： 1986-12-30
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公开(公告)号： US4861774A公开(公告)日： 1989-08-29
- 发明人: Masanobu Kohsaka , Hiroshi Terano , Tadaaki Komori , Morita Iwami , Michio Yamashita , Masashi Hashimoto , Itsuo Uchida , Shigehiro Takase
- 申请人： Masanobu Kohsaka , Hiroshi Terano , Tadaaki Komori , Morita Iwami , Michio Yamashita , Masashi Hashimoto , Itsuo Uchida , Shigehiro Takase
- 申请人地址： JPX Osaka
- 专利权人： Fujisawa Pharmaceutical Co., Ltd.
- 当前专利权人： Fujisawa Pharmaceutical Co., Ltd.
- 当前专利权人地址： JPX Osaka
- 优先权： GBX8416141 19840625; ESX552029 19850214; ESX552030 19850214; GBX8510378 19850424; ZAX85/4469 19850613; AUX43728/85 19850617; CAX484513 19850619; EPX85107681.0 19850621; DKX2855/85 19850624; KRX85-4482 19850624; ESX544482 19850624; TWX74102727 19850624; JPX60-140084 19850625
- 主分类号： A61K31/535
- IPC分类号： A61K31/535 ; A61P31/04 ; A61P35/00 ; C07D498/18 ; C12P17/18 ; C12R1/465
摘要：
The invention relates to a method for treatment of carcinoma or sarcoma tumor in mammals which comprises administering to said mammal an effective amount of a tetracyclo compound of the formula: ##STR1## in which R.sup.1 is formyl, protected formyl, hydroxymethyl, protected hydroxymethyl, arylaminomethyl, carboxy, protected carboxy, aryliminomethyl, hydroxyiminomethyl, alkoxyiminomethyl, acyloxyiminomethyl, semicarbazonomethyl or arylsemicarbazonomethyl,R.sup.2 is hydroxy, alkoxy, or protected hydroxy,R.sup.3 is hydrogen and R.sup.4 is methyl, hydroxymethyl or protected hydroxymethyl, orR.sup.3 and R.sup.4 are combined together to form methylene or oxo,R.sup.5 is hydroxy, alkoxy or protected hydroxy, andR.sup.6 is hydrogen, imino-protective group or alkyl,and pharmaceutically acceptable salts thereof.
公开/授权文献
- US5930149A Test-vector editing system and method 公开/授权日：1999-07-27
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