发明授权
US4868153A Treatment of allograft rejection with mycophenolic acid, its
morpholinoethylester and derivatives thereof
失效
用霉酚酸，其吗啉代乙酯及其衍生物治疗同种异体移植排斥
- 专利标题： Treatment of allograft rejection with mycophenolic acid, its morpholinoethylester and derivatives thereof
- 专利标题（中）： 用霉酚酸，其吗啉代乙酯及其衍生物治疗同种异体移植排斥
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申请号： US233200申请日： 1988-08-17
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公开(公告)号： US4868153A公开(公告)日： 1989-09-19
- 发明人: Anthony C. Allison , Elsie M. Eugui , Peter H. Nelson , Chee-Liang L. Gu , William A. Lee
- 申请人： Anthony C. Allison , Elsie M. Eugui , Peter H. Nelson , Chee-Liang L. Gu , William A. Lee
- 申请人地址： CA Palo Alto
- 专利权人： Syntex (U.S.A.) Inc.
- 当前专利权人： Syntex (U.S.A.) Inc.
- 当前专利权人地址： CA Palo Alto
- 主分类号： C07D307/88
- IPC分类号： C07D307/88
摘要：
The compounds and pharmaceutical compositions of Formula A, wherein Z is hydrogen or --C(O)R, Y is hydrogen or morpholinoethyl, and where R is lower alkyl or aryl, and the pharmaceutically acceptable salts thereof, are useful as immunosuppressive agents, particularly for treatment of allograft rejection, especially including cardiac allograft rejection, pancreatic allograft rejection and renal allograft rejection, and for treating autoimmune diabetes. ##STR1##
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