发明授权
US4870104A 11-haloprostane derivatives, processes for their preparation and their
use as medicinal agents
失效
11-卤代前驱烷衍生物，其制备方法及其作为药物的用途
- 专利标题： 11-haloprostane derivatives, processes for their preparation and their use as medicinal agents
- 专利标题（中）： 11-卤代前驱烷衍生物，其制备方法及其作为药物的用途
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申请号： US929310申请日： 1986-11-12
-
公开(公告)号： US4870104A公开(公告)日： 1989-09-26
- 发明人: Helmut Vorbruggen , Norbert Schwarz , Olaf Loge , Claus-Steffen Sturzebecher , Walter Elger
- 申请人： Helmut Vorbruggen , Norbert Schwarz , Olaf Loge , Claus-Steffen Sturzebecher , Walter Elger
- 申请人地址： DEX Berlin and Bergkamen
- 专利权人： Schering Aktiengesellschaft
- 当前专利权人： Schering Aktiengesellschaft
- 当前专利权人地址： DEX Berlin and Bergkamen
- 优先权： DEX3325175 19830708
- 主分类号： C07D317/16
- IPC分类号： C07D317/16 ; A61K31/557 ; A61K31/5575 ; A61P43/00 ; C07C67/00 ; C07C401/00 ; C07C405/00 ; C07D263/00 ; C07D263/14 ; C07D271/00 ; C07D271/06 ; C07D317/20 ; C07D319/12 ; C07D321/00 ; C07D493/00 ; C07D493/08
摘要：
11-Haloprostane derivatives of general formula I ##STR1## wherein X is F, Cl or Br,R.sub.1 is the residue CH.sub.2 OH or ##STR2## wherein R.sub.2 means a hydrogen atom, an alkyl, cycloalkyl, aryl, phenacyl or heterocyclic residue,A is a --CH.sub.2 --CH.sub.2 -- or cis-CH.dbd.CH-group,B is a --CH.sub.2 --CH.sub.2 -- or trans-CH.dbd.CH-- or a --C.tbd.C-group,W is an ethylenedioxymethylene group or a hydroxymethylene group,D and E together mean a direct bond orD is a C.sub.1-10 -alkylene group,E is an oxygen or sulfur atom, a direct bond, a --C.tbd.C-bond or a --CR.sub.6 .dbd.CR.sub.7 -group with R.sub.6 and R.sub.7 meaning a hydrogen atom, a chlorine atom or an alkyl group,R.sub.4 is a hydroxy group,R.sub.5 is a hydrogen atom, an alkyl, a cycloalkyl, an aryl or a heterocyclic group, andthe salts thereof with physiologically compatible bases, processes for their preparation, and use thereof as agents inhibiting gastric acid secretion.
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