发明授权
- 专利标题: Decahydroquinolines and central analgesic method of use thereof
- 专利标题(中): 十氢喹啉和中枢镇痛药的使用方法
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申请号: US084456申请日: 1987-08-12
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公开(公告)号: US4877796A公开(公告)日: 1989-10-31
- 发明人: Francois Clemence , Odile Le Martret , Francoise Delevallee , Michel Fortin
- 申请人: Francois Clemence , Odile Le Martret , Francoise Delevallee , Michel Fortin
- 申请人地址: FRX Paris
- 专利权人: Roussel Uclaf
- 当前专利权人: Roussel Uclaf
- 当前专利权人地址: FRX Paris
- 优先权: FRX8611620 19860812; FRX8709747 19870709
- 主分类号: A61K31/47
- IPC分类号: A61K31/47 ; A61P7/06 ; A61P7/10 ; A61P9/06 ; A61P9/12 ; A61P25/04 ; C07D215/40 ; C07D401/12 ; C07D409/12
摘要:
A compound selected from the group consisting of all enantiomeric and diastereoisomeric forms of a decahydroquinoline of the formula ##STR1## wherein R.sub.1 is alkyl of 1 to 5 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen and akyl of 1 to 5 carbon atoms, A is selected from the group consisting of --(CH.sub.2).sub.n --, --CH.sub.2 O-- and alkylene substituted with alkyl having a total of 2 to 8 carbon atoms, n is an integer from 0 to 5, Z is selected from the group consisting of optionally substituted phenyl, optionally substituted naphthyl, optionally substituted indenyl, optionally substituted heteromonocycle of 5 to 6 members and optionally substituted heterobicycle with the proviso that when Z is o-alkoxy-phenyl, A is not --(CH.sub.2).sub.n -- in which n is O, and their non-toxic, pharmaceutically acceptable acid addition salts and their quaternary ammonium salts and intermediates having analgesic, diuretic, hypotensive, anti-arrithmic and anti-cerebral-ischaemic properties.
公开/授权文献
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