发明授权
US4879381A 7-(substituted or unsubstituted amino) 3-substituted methyl-.sup.3
cephem-4-carboxylic acid
失效
7-(取代或未取代的氨基)3-取代的甲基-3-头孢烯-4-羧酸
- 专利标题: 7-(substituted or unsubstituted amino) 3-substituted methyl-.sup.3 cephem-4-carboxylic acid
- 专利标题(中): 7-(取代或未取代的氨基)3-取代的甲基-3-头孢烯-4-羧酸
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申请号: US22433申请日: 1987-03-06
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公开(公告)号: US4879381A公开(公告)日: 1989-11-07
- 发明人: Hiroshi Sadaki , Narita Hirokazu , Hiroyuki Imaizumi , Yoshinori Konishi , Takihiro Inaba , Tatsuo Hirakawa , Hideo Taki , Masaru Tai , Yasuo Watanabe , Isamu Saikawa
- 申请人: Hiroshi Sadaki , Narita Hirokazu , Hiroyuki Imaizumi , Yoshinori Konishi , Takihiro Inaba , Tatsuo Hirakawa , Hideo Taki , Masaru Tai , Yasuo Watanabe , Isamu Saikawa
- 申请人地址: JPX Tokyo
- 专利权人: Toyoma Chemical Company, Ltd.
- 当前专利权人: Toyoma Chemical Company, Ltd.
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX55-132253 19800925; JPX55-158184 19801112; JPX55-175263 19801213
- 主分类号: C07D501/24
- IPC分类号: C07D501/24 ; A61K31/545 ; C07D20060101 ; C07D501/04 ; C07D501/18 ; C07D501/20 ; C07D501/38 ; C07D501/40 ; C07D501/46 ; C07D501/56 ; C07D501/57
摘要:
Novel cephalosporins which has attached to the exomethylene group at the 3-position of the cephem ring a substituted or unsubstituted aryl, acylamino, aromatic heterocyclic, triazolyl or tetrazolyl group, said aromatic heterocyclic group being attached through a carbon-carbon bond and said triazolyl or tetrazolyl group being attached through a carbon-nitrogen bond, and has the following group attached to the amino group at the 7-position: ##STR1## wherein A represents a group of the formula, --CH.sub.2 -- or a group of the formula ##STR2## in which R.sup.5 represents a hydrogen atom or an alkyl group, and the bond represents syn or anti isomer or their mixture; R.sup.3 represents a hydrogen or halogen atom; and R.sup.4 represents a hydrogen atom or an amino group which may be protected or substituted. These cephalosporins have a broad antibacterial spectrum, are stable against .beta.-lactamase produced by bacteria, have a low toxicity, and are well absorbed when administered orally or parenterally.
公开/授权文献
- US5960563A Extraction and drying apparatus 公开/授权日:1999-10-05
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