发明授权
- 专利标题: Fused bicyclic imides with psychotropic activity
- 专利标题(中): 稠合双环酰胺具有精神活性
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申请号: US237106申请日: 1988-08-26
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公开(公告)号: US4892943A公开(公告)日: 1990-01-09
- 发明人: Magid A. Abou-Gharbia
- 申请人: Magid A. Abou-Gharbia
- 申请人地址: NY New York
- 专利权人: American Home Products Corporation
- 当前专利权人: American Home Products Corporation
- 当前专利权人地址: NY New York
- 主分类号: C07D401/12
- IPC分类号: C07D401/12 ; C07D403/12
摘要:
There are disclosed compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 represent the structure ##STR2## R.sup.3 and R.sup.4 are hydrogen, or R.sup.3 and R.sup.4 taken together form a 3-5 membered saturated carbocyclic ring;R.sup.5 and R.sup.6 are hydrogen, or R.sup.5 and R.sup.6 taken together form a 3-6 membered carbocyclic ring or a cyclobutenyl ring; with the proviso that when R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are hydrogen, n is other than zero;m is 2-4;n is 0-4;X is lower alkylene, vinylene or O;R.sup.7 is unsubstituted or substituted phenyl, 2-pyridinyl, 2-pyrimidinyl, 2-pyrazinyl or 3-pyridazinyl; where the substituents are selected from the group lower alkyl, lower alkoxy, halo, cyano, nitro and trifluoromethyl;and the pharmaceutically acceptable salts thereof and their use as antipsychotic/anxiolytic agents having a low liability for extrapyramidal side effects.
公开/授权文献
- US5431441A System for controlling safety device for vehicle 公开/授权日:1995-07-11
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