发明授权
US4898949A Intermediates for the preparation of antihypercholesterolemic tetrazole
compounds
失效
用于制备抗高胆固醇血症四唑化合物的中间体
- 专利标题： Intermediates for the preparation of antihypercholesterolemic tetrazole compounds
- 专利标题（中）： 用于制备抗高胆固醇血症四唑化合物的中间体
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申请号： US151512申请日： 1988-02-18
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公开(公告)号： US4898949A公开(公告)日： 1990-02-06
- 发明人: John J. Wright , Sing-Yuen Sit , Neelakantan Balasubramanian , Peter J. Brown
- 申请人： John J. Wright , Sing-Yuen Sit , Neelakantan Balasubramanian , Peter J. Brown
- 申请人地址： NY New York
- 专利权人： Bristol-Myers Company
- 当前专利权人： Bristol-Myers Company
- 当前专利权人地址： NY New York
- 主分类号： A61K31/41
- IPC分类号： A61K31/41 ; A61P3/06 ; C02F11/00 ; C07D257/04 ; C07D405/06 ; C07F9/6524
摘要：
This invention provides novel tetrazole intermediates of the formula ##STR1## wherein R.sup.1 and R.sup.4 each are independently hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or trifluoromethyl;R.sup.2,R.sup.3,R.sup.5 and R.sup.6 each are independently hydrogen, halogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy;B is hydrogen, C.sub.1-4 alkoxycarbonyl, CH.sub.2 Y or CH.sub.2 Z;Y is hydrogen, hydroxyl or X;Z is ##STR2## X is bromo, chloro or iodo; R.sup.10 is C.sub.1-4 alkyl; andR.sup.11 is phenyl which is unsubstituted or substituted by one or two C.sub.1-4 alkyl or chloro substituents.and processes thereof which are useful for the preparation of antihypercholesterolemic agents.
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