发明授权
US4906622A Optically active
2-chloro-12-(3-dimethylamino-2-methyl-propyl)-12H-dibenzo[d.g] [1,3,6]
dioxazocines and a process for the preparation thereof
失效
光学活性的2-氯-12-（3-二甲基氨基-2-甲基 - 丙基）-12H-二苯并[d] [1,3,6]二氧杂吖庚因及其制备方法
- 专利标题： Optically active 2-chloro-12-(3-dimethylamino-2-methyl-propyl)-12H-dibenzo[d.g] [1,3,6] dioxazocines and a process for the preparation thereof
- 专利标题（中）： 光学活性的2-氯-12-（3-二甲基氨基-2-甲基 - 丙基）-12H-二苯并[d] [1,3,6]二氧杂吖庚因及其制备方法
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申请号： US195691申请日： 1988-05-18
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公开(公告)号： US4906622A公开(公告)日： 1990-03-06
- 发明人: Laszlo Rozsa , Lujza Petocz , Eniko Szirt nee Kiszelly , Peter Tompe , Gabor Gigler
- 申请人： Laszlo Rozsa , Lujza Petocz , Eniko Szirt nee Kiszelly , Peter Tompe , Gabor Gigler
- 申请人地址： HUX Budapest
- 专利权人： Egis Gyogyszergyar
- 当前专利权人： Egis Gyogyszergyar
- 当前专利权人地址： HUX Budapest
- 优先权： HUX4881/85 19851220
- 主分类号： A61K31/395
- IPC分类号： A61K31/395 ; A61P25/00 ; A61P25/16 ; C07D273/00 ; C07D273/01
摘要：
The invention relates to optically active 2-chloro-12-(3-dimethylamino-2-methylpropyl)-12H-dibenzo[d,g][1,3,6]dioxazocine of the Formula ##STR1## and pharmaceutically acceptable acid additional salts thereof. The enantiomers are especially active against Parkinsion's disease.The optically active enantiomers are prepared by(a) resolving the racemic 2-chloro-12-(3-dimethylamino-2-methylpropyl)-12H-dibenzo[d,g][1,3,6]-dioxazocine with a optically active organic acid and separating the enantiomers; or(b) dissolving the racemic 2-chloro-12-(3-dimethylamino-2-methylpropyl)-12H-dibenzo[d,g][1,3,6]-dioxazocine in an organic solvent, crystallizing and isolating one of the enantiomers, optionally dissolving additional racemic 2-chloro-12-(3-dimethylamino-2-methylpropyl)-12H-dibenzo[d,g][1,3,6]-dioxazocine in the mother liquor obtained and crystallizing and isolating the other enantiomer, and, if desired, repeating the whole process.
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