• 专利标题: Bicyclo heptane and bicyclo octane substituted inhibitors of cholesterol synthesis
  • 申请号: US287813
    申请日: 1988-12-21
  • 公开(公告)号: US4906657A
    公开(公告)日: 1990-03-06
  • 发明人: Bruce D. Roth
  • 申请人: Bruce D. Roth
  • 申请人地址: NJ Morris Plains
  • 专利权人: Warner-Lambert Company
  • 当前专利权人: Warner-Lambert Company
  • 当前专利权人地址: NJ Morris Plains
  • 主分类号: C07D309/30
  • IPC分类号: C07D309/30
Bicyclo heptane and bicyclo octane substituted inhibitors of cholesterol
synthesis
摘要:
Certain bicyclo [2.2.1] heptane and bicyclo [2.2.2] octane substituted tetrahydro-2H-pyran-2-ones and the corresponding ring-opened acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) and are useful as hypocholesterolemic and hypolipidemic agents.
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