发明授权
US4912219A 2-[4-pyrimidin-2-yl amino)piperidin-1-yl]benzimidazole compound 失效
2- [4-嘧啶-2-基氨基]哌啶-1-基]苯并咪唑化合物

2-[4-pyrimidin-2-yl amino)piperidin-1-yl]benzimidazole compound
摘要:
Benzimidazole derivatives corresponding to the formula (I) ##STR1## in which X is CH or N,R.sub.1 is either a hydrogen atom, or a benzyl radical which can bear 1 to 3 substituents chosen from halogen atoms and trifluoromethyl, (C.sub.1-4)alkyl, (C.sub.1-4)alkoxy, cyano, methylthio, methylsulphinyl and methylsulphonyl radicals, or a methyl radical bearing a heterocyclic substituent in which the heterocyclic system can be a pyridyl, thienyl or furyl radical and can bear one or more substituents,R.sub.2 is a hydrogen atom or a (C.sub.1-4)alkyl radical,R.sub.3 is a hydrogen atom or a hydroxy radical, andR.sub.4 is a hydrogen atom or a (C.sub.1-4)alkyl radical, where appropriate, in tautomeric form when R.sub.3 is OH.The compounds may be used in treating allergy and histamine-induced inflammation.
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