发明授权
US4912219A 2-[4-pyrimidin-2-yl amino)piperidin-1-yl]benzimidazole compound
失效
2- [4-嘧啶-2-基氨基]哌啶-1-基]苯并咪唑化合物
- 专利标题: 2-[4-pyrimidin-2-yl amino)piperidin-1-yl]benzimidazole compound
- 专利标题(中): 2- [4-嘧啶-2-基氨基]哌啶-1-基]苯并咪唑化合物
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申请号: US283468申请日: 1988-12-12
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公开(公告)号: US4912219A公开(公告)日: 1990-03-27
- 发明人: Philippe Manoury , Jean Binet , Gerard Defosse
- 申请人: Philippe Manoury , Jean Binet , Gerard Defosse
- 申请人地址: FRX Paris
- 专利权人: Synthelabo
- 当前专利权人: Synthelabo
- 当前专利权人地址: FRX Paris
- 优先权: FRX8513453 19850911
- 主分类号: A61K31/415
- IPC分类号: A61K31/415 ; A61K31/44 ; A61K31/505 ; A61P29/00 ; A61P37/08 ; A61P43/00 ; C07D401/14 ; C07D405/14 ; C07D409/14 ; C07D471/04
摘要:
Benzimidazole derivatives corresponding to the formula (I) ##STR1## in which X is CH or N,R.sub.1 is either a hydrogen atom, or a benzyl radical which can bear 1 to 3 substituents chosen from halogen atoms and trifluoromethyl, (C.sub.1-4)alkyl, (C.sub.1-4)alkoxy, cyano, methylthio, methylsulphinyl and methylsulphonyl radicals, or a methyl radical bearing a heterocyclic substituent in which the heterocyclic system can be a pyridyl, thienyl or furyl radical and can bear one or more substituents,R.sub.2 is a hydrogen atom or a (C.sub.1-4)alkyl radical,R.sub.3 is a hydrogen atom or a hydroxy radical, andR.sub.4 is a hydrogen atom or a (C.sub.1-4)alkyl radical, where appropriate, in tautomeric form when R.sub.3 is OH.The compounds may be used in treating allergy and histamine-induced inflammation.