发明授权
- 专利标题: 4,5,6,7-Tetrahydroisothiazolo (4,5-c) pyridine derivatives
- 专利标题(中): 4,5,6,7-四氢异噻唑(4,5-c)吡啶衍生物
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申请号: US322632申请日: 1989-03-13
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公开(公告)号: US4923880A公开(公告)日: 1990-05-08
- 发明人: Povl Krogsgaard-Larsen , Erik Falch , Henrik Pedersen
- 申请人: Povl Krogsgaard-Larsen , Erik Falch , Henrik Pedersen
- 申请人地址: DKX Copenhagen-Valby
- 专利权人: H. Lundbeck A/S
- 当前专利权人: H. Lundbeck A/S
- 当前专利权人地址: DKX Copenhagen-Valby
- 优先权: GBX8806013 19880314; GBX8822564 19880926
- 主分类号: A61K
- IPC分类号: A61K20060101 ; A61K31/425 ; A61K31/435 ; A61K31/44 ; A61P25/28 ; C07D20060101 ; C07D513/04
摘要:
The present invention relates to novel compounds of the following formula: ##STR1## individual isomers and pharmaceutically acceptable acid addition salts thereof, whereinR.sup.1 is hydrogen, alkyl or phenyl-lower alkyl, in which the phenyl group may be substituted with halogen, lower alkyl or lower alkoxy;R.sup.2 is alkyl, alkenyl, alkynyl, branched or unbranched, with 1-6 carbon atoms inclusive, which group may be optionally substituted with fluoro, hydroxy or phenyl optionally substituted with halogen, trifluoromethyl, lower alkyl, hydroxy or lower alkoxy;R.sup.3 and R.sup.4 are the same or different, and each represents hydrogen, alkyl(1-6 C-atoms), cycloalkyl (3-6 C-atoms), phenyl optionally substituted with halogen trifluoromethyl, lower alkyl, hydroxy or lower alkoxy, or phenyl-lower alkyl, in which the phenyl group may be substituted with halogen, trifluoromethyl, lower alkyl, hydroxy or lower alkoxy.The invention moreover relates to methods for the preparation of the compounds of formula I, to novel intermediates, to pharmaceutical compositions containing same and to methods for the treatment of disorders, caused by malfunction of the acetylcholine (AcCh) or muscarinic system, by administering a non-toxic effective amount of a compound of formula I.
公开/授权文献
- US5576323A Excitatory amino acid receptor antagonists 公开/授权日:1996-11-19
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