发明授权
- 专利标题： Derivatives of physiologically active substance K-252
- 专利标题（中）： 生理活性物质K-252的衍生物
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申请号： US273519申请日： 1988-11-08
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公开(公告)号： US4923986A公开(公告)日： 1990-05-08
- 发明人: Chikara Murakata , Akira Sato , Mitsuru Takahashi , Eiji Kobayashi , Makoto Morimoto , Shiro Akinaga , Tadashi Hirata , Kenichi Mochida , Hiroshi Kase , Koji Yamada , Kazuyuki Iwashashi
- 申请人： Chikara Murakata , Akira Sato , Mitsuru Takahashi , Eiji Kobayashi , Makoto Morimoto , Shiro Akinaga , Tadashi Hirata , Kenichi Mochida , Hiroshi Kase , Koji Yamada , Kazuyuki Iwashashi
- 申请人地址： JPX Tokyo
- 专利权人： Kyowa Hakko Kogyo Co., Ltd.
- 当前专利权人： Kyowa Hakko Kogyo Co., Ltd.
- 当前专利权人地址： JPX Tokyo
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; C07D20060101 ; C07D498/22
摘要：
The present invention relates to novel derivatives of K-252, (8R*, 9S*, 11S*)-(-)-9-hydroxy-9-methoxycarbonyl-8-methyl-2,3,9,10-tetrahydro-8,11-epoxy-1H,8H, 11H-2,7b,11a-triazadibenzo[a,g]cycloocta-[c,d,e,]trinden-1-one, and the compounds are represented by formula (I): ##STR1## wherein W.sub.1, W.sub.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y represent various substituents. The compounds are physiologically active substances that inhibit protein kinase C and exhibit an antitumor activity, and are useful as medicines.
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