发明授权
US4925877A Physiologically active erbstatin analogue compounds and compositions
失效
生理活性的erbstatin类似物和组合物
- 专利标题： Physiologically active erbstatin analogue compounds and compositions
- 专利标题（中）： 生理活性的erbstatin类似物和组合物
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申请号： US17108申请日： 1987-02-20
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公开(公告)号： US4925877A公开(公告)日： 1990-05-15
- 发明人: Hamao Umezawa, deceased , Tomio Takeuchi , Kuniaki Tatsuta , Kunio Isshika , Masaya Imoto
- 申请人： Hamao Umezawa, deceased , Tomio Takeuchi , Kuniaki Tatsuta , Kunio Isshika , Masaya Imoto
- 申请人地址： JPX Tokyo
- 专利权人： Zaidanhojin Biseibutsu Kagaku Kenkyukai
- 当前专利权人： Zaidanhojin Biseibutsu Kagaku Kenkyukai
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX61-39382 19860225; JPX61-81522 19860408
- 主分类号： A01N37/18
- IPC分类号： A01N37/18 ; A01N47/40 ; A61K31/16 ; A61K31/165 ; A61K31/24 ; A61K31/275 ; C07C233/16
摘要：
The present invention provides new physiological active substance erbstatin analogue compounds of a general formula (I), which have excellent tyrosine-specific protein-kinase inhibitory activity, antitumor activity and antimicrobial activity. ##STR1## (in which R.sup.1 represents a hydrogen atom, a lower alkanoyl group or a lower alkyl group; n represents a positive integer of 1 to 3;X represents a hydrogen atom or a halogen atom;Y represents a group of formula --CH.dbd.CH--NC, --CH.dbd.CH--NHR.sup.2 or --CH.sub.2 --CH.sub.2 --NHR.sup.2(where R.sup.2 represents a formyl group or a lower alkanoyl group; with the exception of the cases where X is hydrogen atom, (R.sup.1 O).sub.n group is 2,5-dihydroxy group and Y is --CH.dbd.CH--NHCHO or --CH.sub.2 --CH.sub.2 --NHCHO).The present invention further provides a tyrosine-specific protein-kinase inhibitor, tumoricide or bactericide containing at least one compound of the said formula (I).
公开/授权文献
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