发明授权
- 专利标题： BMY-28121, a new antitumor antibiotic
- 专利标题（中）： BMY-28121，一种新的抗肿瘤抗生素
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申请号： US31955申请日： 1987-03-30
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公开(公告)号： US4935362A公开(公告)日： 1990-06-19
- 发明人: Mitsuaki Tsunakawa , Masataka Konishi , Takeo Miyaki
- 申请人： Mitsuaki Tsunakawa , Masataka Konishi , Takeo Miyaki
- 申请人地址： NY New York
- 专利权人： Bristol-Myers Company
- 当前专利权人： Bristol-Myers Company
- 当前专利权人地址： NY New York
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C12P17/18
摘要：
A new antitumor antibiotic designated herein as BMY-28121 is produced by fermentation of Streptomyces albus strain K7331-113 (ATCC 39897). BMY-28121, which may be recovered from the fermentation broth in either its natural free hydroxy form (BMY-28121A) or methyl ether form (BMY-28121B), inhibits gram-positive bacteria and anaerobes and inhibits the growth of mammalian tumors such as P-388 leukemia, L-1210 leukemia and B16 melanoma.
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