发明授权
- 专利标题: Polysubstituted thiazolylpyridine carboxyamide antifungal antibiotic
- 专利标题(中): 多取代噻唑吡啶羧酰胺抗真菌抗生素
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申请号: US226016申请日: 1988-07-29
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公开(公告)号: US4956374A公开(公告)日: 1990-09-11
- 发明人: Maki Nishio , Shigeyuki Ando , Takeo Miyaki , Masataka Konishi , Toshikazu Oki
- 申请人: Maki Nishio , Shigeyuki Ando , Takeo Miyaki , Masataka Konishi , Toshikazu Oki
- 申请人地址: NY New York
- 专利权人: Bristol-Myers Company
- 当前专利权人: Bristol-Myers Company
- 当前专利权人地址: NY New York
- 主分类号: C07D417/04
- IPC分类号: C07D417/04 ; C12P17/16
摘要:
Novel antifungal antibiotic compounds have the structural formula ##STR1## A preferred compound where R is 4-hydroxypentyl is denoted BU-3557B.sub.2. A complex of said compounds is produced by fermenting a culture of Sacchrothrix aerocolonigenes strain N806-4 (ATCC 53712). The complex is recovered by adsorption on nonionic porous polymer resin adsorbent and individual component compounds exhibit in vitro activity against fungi and Gram-positive bacteria and BU-3557B.sub.2 demonstrates in vitro antiprotazoal activity. BU-3557B.sub.2 demonstrates in vivo activity against C. albicans vaginal infection and BU-3557A.sub.3 (where R is 1,5-dihydroxy-5,5-dimethylpentyl) demonstrates in vivo activity against C. albicans systemic infection.