发明授权
- 专利标题: Prolinal compounds useful in treating amnesia
- 专利标题(中): 可用于治疗遗忘症的肛门化合物
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申请号: US123410申请日: 1987-11-20
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公开(公告)号: US4956380A公开(公告)日: 1990-09-11
- 发明人: Masaaki Toda , Shuichi Ohuchida , Hiroyuki Ohno
- 申请人: Masaaki Toda , Shuichi Ohuchida , Hiroyuki Ohno
- 申请人地址: JPX Osaka
- 专利权人: Ono Pharmaceutical Co., Ltd.
- 当前专利权人: Ono Pharmaceutical Co., Ltd.
- 当前专利权人地址: JPX Osaka
- 优先权: JPX61-275375 19861120; JPX62-228452 19870914
- 主分类号: A61K31/40
- IPC分类号: A61K31/40 ; A61K31/401 ; A61K31/4025 ; A61K31/435 ; A61K31/44 ; A61K31/4427 ; A61K31/443 ; A61K31/4433 ; A61P25/28 ; C07D207/08 ; C07D401/12 ; C07D405/12 ; C07D409/12
摘要:
Novel prolinal derivatives of the general formula: ##STR1## wherein A represents alkylene group of from 1 to 8 carbon atoms or alkenylene group of from 2 to 8 carbon atom(s) or a saturated hydrocarbon ring of from 3 to 7 carbon atoms, R represents hydrogen atom, phenyl group, benzyl group, alkyl group of from 1 to 8 carbon atom(s) or cycloalkyl group of from 3 to 7 carbon atoms,B represents alkylene group of from 1 to 8 atom(s) unsubstituted or substituted by phenyl group or benzyl group, or a single bond,D represents carbocyclic or heterocyclic ring unsubstituted or substituted by from one to three of halogen atom, alkyl or alkoxy group of from 1 to 4 carbon atom(s), nitro group or trifluoromethyl group which prolinal derivatives possess inhibitory activity on prolyl endopeptidase, and therefore are useful as a treating or preventing agent for amnesia.
公开/授权文献
- US6011202A Soybean cultivar 95-00981 公开/授权日:2000-01-04