发明授权
US4960770A 2-alkyl thieno(triazolo)diazepine compounds and pharmaceutical uses
thereof
失效
2-三烷基噻吩并（三唑并）二氮杂化合物及其药物用途
- 专利标题： 2-alkyl thieno(triazolo)diazepine compounds and pharmaceutical uses thereof
- 专利标题（中）： 2-三烷基噻吩并（三唑并）二氮杂化合物及其药物用途
-
申请号： US304989申请日： 1989-01-11
-
公开(公告)号： US4960770A公开(公告)日： 1990-10-02
- 发明人: Minoru Moriwaki , Masao Abe , Hiroshi Mikashima , Tetsuya Tahara
- 申请人： Minoru Moriwaki , Masao Abe , Hiroshi Mikashima , Tetsuya Tahara
- 申请人地址： JPX Osaka
- 专利权人： Yoshitomi Pharmaceutical Industries, Ltd.
- 当前专利权人： Yoshitomi Pharmaceutical Industries, Ltd.
- 当前专利权人地址： JPX Osaka
- 优先权： JPX62-132058 19870528; JPX62-137195 19870529; JPX62-149698 19870616
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; A61P7/00 ; A61P9/00 ; A61P9/08 ; A61P9/10 ; C07D495/04 ; C07D495/14
摘要：
A thienotriazolodiazepine compound of the formula: ##STR1## wherein Ar is phenyl, pyridyl, substituted phenyl or substituted pyridyl; R.sup.1 and R.sup.3 are the same or different and each is hydrogen, alkyl having 1 to 4 carbon atoms; R.sup.2 is hydrogen, alkyl having 1 to 4 carbon atoms or trifluoromethyl; R.sup.4 is straight or branched chain alkyl, alkenyl or alkynyl having 6 to 18 carbon atoms, or a thienodiazepine compound of the formula: ##STR2## wherein Ar, R.sup.1, R.sup.2 and R.sup.4 are as defined above, and pharmaceutically acceptable acid addition salt thereof.These compounds are useful as drugs for the treatment of circulatory diseases and various PAF-induced diseases. The compound (II) is also useful as an intermediate for preparing the compound (I).
公开/授权文献
信息查询
