An electrophotographic lithographic printing plate precursor comprising a conductive support having provided thereon at least one photoconductive layer containing photoconductive zinc oxide and a resin binder, wherein said resin binder comprises (A) at least one resin containing at least one functional group capable of forming at least one hydrophilic group selected from a thiol group, a phosphono group, an amino group, and a sulfo group upon decomposition and at least one of (B) a heat-curable and photo-curable resin and (C) a crosslinking agent. The printing plate precursor provides a printing plate exhibiting excellent resistance to background stains and printing durability.