发明授权
- 专利标题: Phenylthioheterocyclic derivatives
- 专利标题(中): 苯硫杂环衍生物
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申请号: US323583申请日: 1989-03-14
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公开(公告)号: US4973599A公开(公告)日: 1990-11-27
- 发明人: Norman W. Gilman , Wen Y. Chen
- 申请人: Norman W. Gilman , Wen Y. Chen
- 申请人地址: NJ Nutley
- 专利权人: Hoffman-La Roche Inc.
- 当前专利权人: Hoffman-La Roche Inc.
- 当前专利权人地址: NJ Nutley
- 主分类号: C07D233/84
- IPC分类号: C07D233/84 ; C07D239/38 ; C07D277/36
摘要:
Compounds of the formula ##STR1## wherein n is a integer of 0 to 2; R.sub.1 ' and R.sub.2 ' are, independently, hydrogen, halogen, trifluoromethyl, lower alkoxy or lower alkyl; and X is pyrimidinyl, thiazolyl or ##STR2## wherein R is hydrogen, lower alkyl, aryl or ar-lower alkyl; provided that at least one or R.sub.1 ' and R.sub.2 ' is other than hydrogen,and their pharmaceutically acceptable acid addition salts, and an anti-inflammatory method utilizing a compound of the formula ##STR3## wherein n is an integer of 0 to 2; R.sub.1 and R.sub.2 are, independently, hydrogen, halogen, trifluoromethyl, nitro, amino, lower alkylamino, di-lower-alkylamino, lower alkoxy or lower alkyl; and X is pyrimidinyl, thiazolyl or ##STR4## wherein R is hydrogen, lower alkyl, aryl or ar-lower alkyl; and their pharmaceutically acceptable acid addition salts, are described.
公开/授权文献
- US5493792A Shoe comprising liquid cushioning element 公开/授权日:1996-02-27