A sterile disposable plastic cover for a handle of an operating room fixture such as a cylindrical handle for a light fixture is disclosed. The cover includes a hollow member which is open at one end and includes a hand guard. The open end is partially restricted with a retention member which permits the handle of the operating fixture to extend through the open end of the hollow member and holds it in place. Preferably, the retention member is a disc which includes a pair of intersecting slits which define an opening smaller than the opened end of the hollow member.