A gabexate mesylate ointment according to the present invention comprises 0.01-8% by weight of gabexate mesylate, 25-80% by weight of white vaseline, and 20-75% by weight of at least one type of viscosity controller selected from the group consisting of liquid parrafin, squalene and fatty acid ester containing 8-20 carbon atoms. Where desirable, this ointment is added with 1-20% by weight of at least one type of viscosity controlling auxiliary selected from the group consisting of higher alcohol and higher fatty acid containing 14-34 carbon atoms, beeswax and spermaceti wax.