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发明授权
US4980347A Platinum complex, process for preparing same and antitumor agent 失效
铂复合物，其制备方法和抗肿瘤剂

Platinum complex, process for preparing same and antitumor agent
摘要：
A platinum complex represented by the formula: ##STR1## where X is ##STR2## wherein R.sup.1 is a (C1-18) alkyl group, a (C1-18)alkenyl group or a group --Z--R.sup.4 in which Z is --CH.dbd.CH-- or a (C1-5)alkylene group, and R.sup.4 is a phenyl group, a hydroxyphenyl group, a (C7-12)alkoxyphenyl group, a halogenophenyl group, a nitrophenyl group, or (C8-13)alkoxycarbonylphenyl group, a cyclohexyl group having a (C1-5)alkyl substituent, ##STR3## R.sup.2 is hydrogen or a (C1-18)alkyl group, R.sup.3 is hydrogen or a (C1-3) alkyl group, R.sup.2 and R.sup.3 are linked together to form a (C2-7)alkylene group; the dotted line indicates that the bond may be either a single bond or a double bond; the chain line indicates a conjugated system; the 1,2-diaminocyclohexane moiety has a cis-, trans-l- or trans-d-configuration; and Y is an anion. This platinum complex is useful in the treatment of tumors.
摘要（中）：

由下式表示的铂络合物：其中X为，其中R1为（C1-18）烷基，（C1-18）烯基或-Z-R4基团，其中Z 是-CH = CH-或（C1-5）亚烷基，R4是苯基，羟基苯基，（C7-12）烷氧基苯基，卤代苯基，硝基苯基或（C8-13） 烷氧基羰基苯基，具有（C1-5）烷基取代基的环己基，R2是氢或（C1-18）烷基，R3是氢或（C1-3）烷基，R2和R3连接 一起形成（C2-7）亚烷基; 虚线表示该键可以是单键或双键; 链线表示共轭系统; 1,2-二氨基环己烷部分具有顺式，反式-1-或反式-d构型; Y为阴离子。 该铂络合物可用于治疗肿瘤。

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