发明授权
- 专利标题: Method for production of cephalosporin compounds
- 专利标题(中): 生产头孢菌素化合物的方法
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申请号: US373594申请日: 1989-06-30
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公开(公告)号: US4980464A公开(公告)日: 1990-12-25
- 发明人: Kenzo Naito , Yukio Ishibashi
- 申请人: Kenzo Naito , Yukio Ishibashi
- 申请人地址: JPX Osaka
- 专利权人: Takeda Chemical Industries, Ltd.
- 当前专利权人: Takeda Chemical Industries, Ltd.
- 当前专利权人地址: JPX Osaka
- 优先权: JPX61-44992 19860228
- 主分类号: A61K31/545
- IPC分类号: A61K31/545 ; A61K31/546 ; A61P31/04 ; C07D501/04 ; C07D501/18 ; C07D501/20 ; C07D501/24 ; C07D501/26 ; C07D501/46 ; C07D519/06 ; C07F7/10
摘要:
A method for producing a compound of the formula; ##STR1## wherein R stands for a hydrogen atom, an acyl group or a protective group other than acyl groups, Q stands for a hydrogen atom or an ester residue, Y stands for the residue of a nucleophilic compound and the dotted line shows the double bond at 2- or 3- position of the cephem ring or a salt thereof, characterized by allowing a compound of the formula; ##STR2## [R, Q and the dotted line are of the same meaning as above] or a salt thereof to react with a nucleophilic compound or a salt thereof and a compound of the formula; ##STR3## wherein R.sup.1, R.sup.2, R.sup.3 independently stand for a hydrocarbon group having not more than 8 carbon atoms, or R.sup.1 and R.sup.2, R.sup.1 and R.sup.3 or R.sup.2 and R.sup.3 may be combined to form polymethylene group, according to which the end product [I] of high quality can be provided in a high yield by one reaction step by using the compound [III] of relatively low cost, thus the method of this invention is advantageous for mass-producing the compound [I] on an industrial scale from the compound [II] and a nucleophilic compound.
公开/授权文献
- US5741432A Stabilized nitric acid compositions 公开/授权日:1998-04-21