发明授权
US4983396A Percutaneous penetration enhancer of oleic acid and
2-ethyl-1,3-hexanediol
失效
油酸和2-乙基-1,3-己二醇的经皮穿透增强剂
- 专利标题: Percutaneous penetration enhancer of oleic acid and 2-ethyl-1,3-hexanediol
- 专利标题(中): 油酸和2-乙基-1,3-己二醇的经皮穿透增强剂
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申请号: US412730申请日: 1989-09-26
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公开(公告)号: US4983396A公开(公告)日: 1991-01-08
- 发明人: Nicholas Bodor , Thorsteinn Loftsson
- 申请人: Nicholas Bodor , Thorsteinn Loftsson
- 申请人地址: NJ Kenilworth
- 专利权人: Key Pharmaceuticals, Inc.
- 当前专利权人: Key Pharmaceuticals, Inc.
- 当前专利权人地址: NJ Kenilworth
- 主分类号: A61K9/70
- IPC分类号: A61K9/70 ; A61K31/21 ; A61K31/565 ; A61K47/10 ; A61K47/12
摘要:
Pharmaceutical preparations comprised of a pharmaceutically active ingredient and a carrier which comprises a percutaneous penetration enhancer comprised of 2-ethyl-1, 3-hexanediol alone or in combination with oleic acid is disclosed. The 2-ethyl-1, 3-hexanediol may be present in an amount in the range of about 50% to 100% based on the weight of the carrier. The oleic acid may be used in combination with 2-ethyl-1, 3-hexanediol in an amount of about 1 to 40% based on the weight of the carrier to provide a synergistic effect with respect to percutaneous penetration enhancement. The compound 2-ethyl-1, 3-hexanediol as used alone and/or in combination with the oleic acid has been found to significantly enhance the delivery of a drug, to a patient, from a transdermal delivery system.