An apparatus for driving a color display panel operating at a high frame frequency. The color display panel driving apparatus includes a line memory for storing data of 1/2 of a line at its odd-numbered addresses and then storing data of the remaining 1/2 of the line at its even-numbered addresses, a first column drive circuit including a shift register to which the data stored at the odd-numbered addresses of the line memory are supplied and which is connected at its bit outputs to column-direction signal wires associated with a left-hand half display area of the display panel, and a second column drive circuit including a shift register to which the data stored at the even-numbered addresses of the line memory are supplied and which is connected at its bit outputs to column-direction signal wires associated with a right-hand half display area of the display panel. After picture data of one line are completely stored in the line memory, the picture data are substantially simultaneously supplied from the odd-numbered and even-numbered addresses of the line memory to the first and second column drive circuits respectively.