发明授权
- 专利标题： Phenylene derivatives and anti-allergic use thereof
- 专利标题（中）： 苯衍生物及其抗过敏用途
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申请号： US899218申请日： 1986-08-15
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公开(公告)号： US4994479A公开(公告)日： 1991-02-19
- 发明人: Toshiyasu Mase , Kiyoshi Murase , Hiromu Hara , Kenichi Tomioka
- 申请人： Toshiyasu Mase , Kiyoshi Murase , Hiromu Hara , Kenichi Tomioka
- 申请人地址： JPX Tokyo
- 专利权人： Yamanouchi Pharmaceutical Co., Ltd.
- 当前专利权人： Yamanouchi Pharmaceutical Co., Ltd.
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX60-70566 19850403; JPX60-297096 19851226
- 主分类号： A61K31/195
- IPC分类号： A61K31/195 ; C07C45/71 ; C07C47/575 ; C07C59/70 ; C07C59/72 ; C07C59/90 ; C07C65/21 ; C07C65/24 ; C07C69/712 ; C07C69/734 ; C07C233/12 ; C07C235/56 ; C07C235/64 ; C07C255/59 ; C07C255/60 ; C07C271/28 ; C07C275/40 ; C07D257/04 ; C07D285/12 ; C07D285/125 ; C07D285/135
摘要：
Novel phenylene derivatives shown by the general formula ##STR1## wherein A represents a hydrogen atom, a phenyl group or a phenoxy group, n represents an integer of 3 to 10, R.sub.1 represents a hydrogen atom or a lower alkoxy group, X.sub.1 represents --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --CONH--, .circle.B represents ##STR2## (wherein R.sub.2 represents a hydrogen atom, a halogen atom, a nitro group, etc.), ##STR3## (wherein R.sub.3 represents a hydrogen atom, a hydroxyl group or a lower alkoxy group), X.sub.2 represents --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, etc. and D represents a carboxy group, a lower alkoxycarbonyl group or ##STR4## which are useful as drugs, particularly SRS-A (slow reacting substance of anaphylaxis) antagonist, i.e. they are useful as prophylaxis and treatment for various allergic diseases (e.g. bronchial asthma, allergic rhinitis, urticaria) or, ischemic heart diseases, inflammation, etc. induced by SRS-A.
公开/授权文献
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