发明授权
US5002942A 1,5-benzothiazepine derivatives, their preparation and their use in the
treatment of cardiovascular disorders
失效
1,5-苯并硫氮因衍生物,其制备及其在治疗心血管疾病中的应用
- 专利标题: 1,5-benzothiazepine derivatives, their preparation and their use in the treatment of cardiovascular disorders
- 专利标题(中): 1,5-苯并硫氮因衍生物,其制备及其在治疗心血管疾病中的应用
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申请号: US384261申请日: 1989-07-21
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公开(公告)号: US5002942A公开(公告)日: 1991-03-26
- 发明人: Hiroaki Yanagisawa , Koichi Fujimoto , Yasuo Shimoji , Takuro Kanazaki , Hiroyuki Koike , Hiroshi Nishino
- 申请人: Hiroaki Yanagisawa , Koichi Fujimoto , Yasuo Shimoji , Takuro Kanazaki , Hiroyuki Koike , Hiroshi Nishino
- 申请人地址: JPX Tokyo
- 专利权人: Sankyo Company, Limited
- 当前专利权人: Sankyo Company, Limited
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX63-185097 19880725; JPX63-267540 19881024; JPX1-41024 19890221
- 主分类号: C07D281/10
- IPC分类号: C07D281/10 ; C07D417/04 ; C07D417/06
摘要:
Compounds of formula (I): ##STR1## in which: R.sup.1 is aryl or aromatic heterocyclic; R.sup.2 and R.sup.3 are hydrogen, alkyl, alkoxy, halogen, phenyl, phenoxy, C.sub.1 -C.sub.6 alkylthio, phenylthio, C.sub.1 -C.sub.6 haloalkyl, cyano or nitro, or together are alkylene optionally containing oxygen; R.sup.4 is hydrogen, aliphatic acyl, cycloalkylcarbonyl, cycloalkoxycarbonyl, aromatic acyl, alkoxycarbonyl or benzyloxycarbonyl; R.sup.5 and R.sup.6 are alkyl; and X is oxygen, sulfur or methylene, have calcium channel blocking activity and can serve for the treatment or prophylaxis of cardiovascular diseases and disorders. They may be prepared by reacting a corresponding compound where R.sup.4 is hydrogen and the aminoethyl group is replaced by hydrogen with a compound providing the aminoethyl group and the, if required, acylating the product.
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