发明授权
- 专利标题: Chemical compounds
-
申请号: US493250申请日: 1990-03-14
-
公开(公告)号: US5023255A公开(公告)日: 1991-06-11
- 发明人: Frank Ellis , Alan Naylor , Christopher J. Wallis , Ian Waterhouse
- 申请人: Frank Ellis , Alan Naylor , Christopher J. Wallis , Ian Waterhouse
- 申请人地址: GB2
- 专利权人: Glaxo Group Limited
- 当前专利权人: Glaxo Group Limited
- 当前专利权人地址: GB2
- 优先权: GBX8905914 19890315; GBX8924135 19891026; GBX8924138 19891026
- 主分类号: C12N9/99
- IPC分类号: C12N9/99 ; A61K31/53 ; A61P29/00 ; A61P37/08 ; A61P43/00 ; C07C281/02 ; C07C281/06 ; C07D233/64 ; C07D253/06 ; C07D281/02 ; C07D401/12 ; C07D413/12 ; C07D417/12
摘要:
Triazine derivatives of formula (I) ##STR1## or salts thereof, whereinR.sup.1 represents a halogen atom or a group selected from hydroxy; C.sub.1-8 alkyl C.sub.1-6 alkoxy; C.sub.1-3 alkoxy C.sub.1-3 alkoxy; phenoxy or phenyl C.sub.1-3 alkoxy, wherein the phenyl group is optionally substituted by a halogen atom or a group selected from C.sub.1-3 alkyl, C.sub.1-3 alkoxy, or hydroxy; fluoro C.sub.1-3 alkyl; cyano; --CO.sub.2 R.sup.3, wherein R.sup.3 represents a hydrogen atom or a C.sub.1-4 alkyl group; --CONR.sup.4 R.sup.5, wherein R.sup.4 and R.sup.5 each independently represents a hydrogen atom or a C.sub.1-4 alkyl group, or, together with the nitrogen atom to which they are attached, form a saturated 5- to 7- membered ring, which ring optionally contains one or more atoms selected from an oxygen or a sulphur atom, or a group selected from --NH-- or --N(CH.sub.3)--; andR.sup.2 represents a hydrogen or halogen atom, or a group selected from hydroxy, C.sub.1-6 alkyl or C.sub.1-6 alkoxy;are inhibitors of the enzyme 5-lipoxygenase.Processes for preparing the triazine derivatives of formula (I) and compositions containing them are also described.
信息查询